KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (alpha-MSH). It represents the core anti-inflammatory fragment of alpha-MSH, retaining the anti-inflammatory properties of the full peptide while being a smaller, more stable molecule. KPV acts at MC1R and MC3R receptors and directly inhibits NF-κB signaling — one of the master regulators of the inflammatory cascade.
KPV has garnered research interest for inflammatory bowel disease (IBD) research, wound healing, and anti-inflammatory protocols. Its small size (tripeptide) provides stability advantages and potential for mucosal delivery that larger peptides don't share. It is often studied alongside GHK-Cu in skin biology research (KLOW Stack) and alongside BPC-157 in gut healing protocols.
Third-party tested · Lot-specific COA · US domestic shipping 24–48h
Buy KPV Now →| Purity | ≥99% (HPLC verified, third-party) |
| Molecular Weight | 340.4 Da |
| Appearance | White lyophilized powder |
| Storage | –20°C long-term; 4°C up to 14 days after reconstitution |
| Lot Number | OL-2026-018 |
| Format | Lyophilized powder, sealed vial |
| Certificate of Analysis | Lot-specific COA included with every order |
| Intended Use | In vitro laboratory research only |
| Sequence | Lys-Pro-Val (alpha-MSH C-terminal fragment) |
Research Use Disclaimer: KPV is sold strictly for in vitro laboratory research purposes only. Not for human consumption, veterinary use, or clinical application. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.